However, there is a lack of evidence regarding the efficacy of this drug in preventing serious respiratory complications in most studies.26 Interestingly,
some authors suggested, using animal models, that more than one antiviral drug is necessary to prevent complications in influenza A(H1N1)pdm09 infections.27 No association was found between abnormalities on chest X-rays and need for MV, but this analysis had serious limitations because the authors only had access to reports of findings. As this was a retrospective study, it has several limitations, such as loss and lack of accurate data, which led to the exclusion of blood cell count from the analysis, for example, besides all aforementioned limitations. It was not possible to know whether the 16 patients not included buy Everolimus biased the findings, since their demographic data was not assessed. Nevertheless, the authors believe that the present study is relevant because it is one
of the first to assess risk factors for respiratory PCI-32765 supplier complications in Brazilian children with influenza A(H1N1)pdm09 infections, since there are few reports assessing pediatric hospitalizations during the pandemic in Brazil.28 The present findings highlight that all deaths occurred in the group indicated for antiviral treatment by the local public health authorities’ recommendations during the pandemic, reinforcing that high risk groups of children are more predictable than those of adults, in which more than 30% of deaths usually occur in patients without an identifiable predictor of poorer outcome.29 This information is very helpful to guide future preventive and therapeutic interventions. Viral co-detection may be a new identified predictor of complications, although more studies are necessary to confirm this association, preferably using more sensitive techniques such as RT-PCR. The authors declare
no conflicts of interest. The authors C-X-C chemokine receptor type 7 (CXCR-7) would like to thank the Rio Grande do Sul Health Departmentfor supplying the names of patients with confirmed infection. They also thank all participanting institutions for allowing data collection. “
“In spite of advances in obstetric care and intrapartum use of antimicrobial agents for streptococcal infection prophylaxis, neonatal sepsis remains an important cause of morbidity and mortality in newborns (NBs), especially in those who weigh less than 1,500 g.1, 2, 3, 4, 5, 6 and 7 The clinical picture of neonatal sepsis and laboratory diagnosis are usually nonspecific.8 and 9 Blood cultures, which are considered the gold standard, have widely variable positive results and may be false negative in 20% of cases; moreover, their results are not readily available to define the therapeutic conduct.