0%) showed CR. Five (20%) of these patients in CR
who underwent allogeneic HSCT are still in remission. The remaining 20 (80.0%) children were lost due to infection or relapse of the primary diseases. The overall survival of patients who are still alive and underwent allogeneic HSCT (mean: 40.6 +/- 4.7, median: 40, range: 34-46 months) was longer than that of patients (mean: 5.5 +/- 4.3, median: 4, range: 1-15 months) who did not undergo allogeneic HSCT. The CR rate was quite high in the present study using the FLAG-IDA regimen, and the authors believe this regimen is a possible option prior to allogeneic HSCT in children with poor-prognosis acute leukemia.”
“We predict that undoped nanoparticles (size <= 10-100 nm) of incipient ferroelectrics without any magnetic ions can become ferromagnetic even at room temperatures due to the inherent presence of a new type of magnetic defects with PF-562271 spin S = 1, namely oxygen vacancies, where the magnetic triplet state is the CHIR98014 order ground state in the vicinity of the surface (magnetic shell), while the nonmagnetic singlet is the ground state in the bulk material (nonmagnetic core). In particular, for a particle radii R less
than the critical radius R(c)(T) ferromagnetic long-range order appears in a shell region of thickness 5-50 nm once the concentration of magnetic defects N exceeds the magnetic percolation threshold N(p). At vacancy concentrations N<N(p) and radii R<R(c)(T), short-range ferromagnetic order and consequently a spin glass state may appear. For particle radii R>R(c)(T), only the paramagnetic phase is possible. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3580478]“
“Aim: The aim of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1), TRF2 and protection of telomeres 1 (POT1) in gastric cancer and their relationships with clinicopathological features and telomerase activity.
Methods: In total 36 gastric cancer tissue and see more paired adjacent normal tissue were analyzed. The mRNA expression of telomere binding proteins TRF1,
TRF2 and POT1 were measured using quantitative reverse transcription polymerase chain reaction, and telomerase activity was assessed by the telomeric repeat amplification protocol/enzyme linked immunosorbent assay method.
Results: The expression of POT1 was significantly higher in tumor tissue than in adjacent normal tissue (P < 0.001). Levels of TRF2 mRNA were significantly higher in bigger tumors (diameter >= 5 cm) than in small tumors (diameter < 5 cm) (P = 0.043). POT1 mRNA transcription levels were higher in tumors with lymph nodes metastases than in those without lymph nodes metastases (P = 0.048). POT1 expression was significantly correlated with tumor stage (P = 0.008). A higher level of expression of POT1 was observed in late-stage tumors (III, IV) than in early stage tumors (I, II).