05), the XIAP expression of extent of the ulcer before and after treatment no significant difference (P > 0.05). Conclusion: Smac expression to promote apoptosis of gastric epithelial cells, may lead to gastric ulcers, the development and impact

of its healing; XIAP high expression may play an important role in the healing of mucosal repair, and ulcers. Smac and XIAP may be an important part of the HP-induced gastric ulcer occurs apoptosis signaling network. Key Word(s): 1. Gastric ulcer; 2. Smac; 3. XIAP; 4. apoptosis; Presenting Author: YING LUO Additional Authors: LINGXIAO BU, YIQI WANG, HONGWEI SHA Corresponding PD-1/PD-L1 activation Author: YIQI WANG Affiliations: Guangdong General Hospital Objective: Gastroesophageal reflux disease questionnaires (GerdQ) has been applied as a screening diagnostic test for gastroesophageal reflux disease (GERD) in western country. But the value of GerdQ in Chinese people remained uncertain. So the aims of the study were to assess the validation of GerdQ for the diagnosis of GERD and to explore the optimal diagnostic critical value of GerdQ for Chinese people. Methods: Patients with heartburn and/or regurgitation selected from outpatient service were presented with a six-item GerdQ, which included heartburn, reflux, epigastric pain, nausea, sleep disturbance, and additional medicine. Gastroscopy

and 24-hour esophageal pH-impedance monitoring were also carried out in these patients. The patients with esophagus erosion under gastroscopy or/and the DeMeester Score PLX3397 mw 3-mercaptopyruvate sulfurtransferase more than 14.72 were diagnosed as GERD. The results were compared with GerdQ score to determine the diagnostic cut-off score for GERD. Results: A total of 122 patients with reflux-related symptoms were questionaired, including 63 male and 59 female. When the GerdQ cut-off score came to 9, the maximal Youden index was 0.358 and the area under receiver operating characteristic was 0.699, with the sensitivity of

80.23%, specificity of 55.56%, as well as the true positive diagnostic rate of 81.18% and true negative diagnostic rate of 54.05%. Conclusion: GerdQ is approved as a suitable, easy handle method in initial diagnosis of GERD. The diagnostic score of GerdQ for Chinese people is 9, which is different from that for western people. Key Word(s): 1. GERD; 2. GerdQ; 3. gastroscopy; 4. pH monitoring; Presenting Author: GALYNAD. FADIEIENKO Additional Authors: OLHAV. CHYRVA Corresponding Author: GALYNAD. FADIEIENKO, OLHAV. CHYRVA Affiliations: SI “Institute of Therapy named after L.T. Malaya of NAMS of Ukraine Objective: Combination of neurocirculatory dystonia (NCD) and functional dyspepsia (FD) is often associated with the phenomenon of mutual burdening and has a potential role in quality of life in young patients. The study was designed to assess the main indices of quality of life in these patients. Methods: 69 persons from organized student population (21 males, 48 females) aged 18 – 27 with cardial form of NCD were included in this study.