Outcome parameters were survival, cardiac allograft vasculopathy (CAV), and cellular rejection.
Results: We retrospectively selected 159 patients: 107 with 0 or 1 rejection and 52 with 2 or more acute rejection episodes, of whom 36 (22.6%) had a positive screen for anti-MICA antibodies. In 19 of 36 samples, specific anti-MICA antibodies were confirmed Flavopiridol in vivo by single antigen assay. The presence of post-transplant specified anti-MICA antibodies in patients’ sera was associated with acute rejection (63.2% vs; 28.6%, p < 0.01)
and CAV (78.9% vs 32.8%, p < 0.01). Multivariate analysis identified anti-MICA positivity as an independent risk factor for the development of CAV.
Conclusions: The results indicate that anti-MICA antibodies may be related to adverse outcome after heart transplantation.
selleck kinase inhibitor Post-transplantation monitoring of anti-MICA antibodies could identify patients with an increased risk for acute rejection and vasculopathy. J Heart Lung Transplant 2009;28:305-11. Copyright (C) 2009 by the International Society for Heart and Lung Transplantation.”
“Limited access to sterile syringes and condoms in correctional facilities make these settings high risk environments for HIV transmission. Although incarceration among injection drug users (IDUs) is common, there is limited information regarding specific IDU risk behaviors inside. We examined correlates of incarceration, injection inside and syringe sharing inside among male IDUs recruited in Tijuana. Mexico, using respondent driven sampling (RDS) (n = 898). An interviewer administered survey collected data on sociodemographic, behavioral and contextual characteristics. Associations with (a) history of incarceration, (b) injection
inside, and (c) syringe sharing inside were identified using univariate and multiple logistic regression models with RDS adjustment. Seventy-six percent of IDUs had been incarcerated, of whom 61% injected inside. Three quarters (75%) of those who injected shared syringes. U.S. deportation [adjusted odds ratio (AOR) = 1.61; 95% confidence interval (CI): 1.07, 2.43] and migration (AOR = 1.81; 95% CI: 1.12,2.95) were independently associated with incarceration. Injection inside was independently associated with PF-02341066 in vitro recent receptive syringe sharing (AOR = 2.46; 95% CI: 1.75, 3.45) and having sex with a man while incarcerated (ACR = 3.59; 95% CI: 1.65, 7.83). Sharing syringes inside was independently associated with having sex with a man while incarcerated (AOR = 6.18; 95% CI: 1.78, 21.49). A Majority of incarcerated IDUs reported injecting and syringe sharing during incarceration. and these IDUs were more likely to engage in sex with other men. Corrections-based interventions to reduce injection and syringe sharing are urgently needed, as are risk reduction interventions for male IDUs who have sex with men while incarcerated. (C) 2009 Elsevier Ireland Ltd. All rights reserved.