1 (3.1) −2.1 (−3.2– − 0.9)* SF-36#  Physical function 80.5 (8.2) 96.6 (5.7) 16.1 (12.9–19.3)* 69.8 (22.8) 94.7 (8.1) 24.9 (19.8–30.0)*  Physical role 80.4 (32.8) 93.1 (19.2) 12.7 (1.3–24.1)* 56.6 (43.5) 93.4 (19.6) 36.8 (26.4–47.2)*  Bodily pain 71.9 (12.8) 90.3 (12.7) 18.4 (11.5–25.3)* 64.3 (19.1) 92.1 (9.9) 27.8 (23.2–32.4)*  General health 48.2 (18.3) 75.0 (13.7) 26.8 (19.2–34.4)*

52.6 (18.7) 76.7 (15.0) 24.1 (18.4–29.8)*  Social function 92.0 (11.6) 91.3 (13.2) −0.70 (−7.8–6.4) 74.5 (20.4) 90.6 (11.8) 16.1 (11.0–21.2)*  Emotional role 95.2 (17.8) 96.7 (15.3) 1.5 (−6.9–9.9) 82.0 (32.9) 91.8 (23.5) 9.8 (1.0–18.6)*  Mental health 80.6 (11.3) 72.4 (10.2) −8.2 (−13.8– − 2.6)* 73.7 (13.7) 71.0 (9.0) −2.7 (−6.3–0.9)  Vitality 66.4 (13.2) 69.1 (11.5) 2.7 (−3.6–9.0) 59.8(16.6) 66.0 (13.0) 6.2 (1.6–10.8)* Differences between early OA (CHECK) and healthy workers

* p < 0.05; CP673451 research buy OICR-9429 solubility dmso # mean (SD) Health status comparison The subjects with OA reported statistically significantly lower scores than the healthy workers on the physical component of SF-36, for both sexes. Atezolizumab supplier Because of the higher mean age and the small number of the male subjects with OA, afterwards a corrected analysis was performed, in which they were compared to an age-matched subsample of 30 healthy workers (mean age 58). Table 2 FCE performances of male subjects with early OA (CHECK, n = 15) and male healthy workers (n = 183) FCE test Age category # (years) Early OA mean (SD) Healthy workers mean (SD) Mean CHIR-99021 difference healthy—early OA (95% CI) Lifting low (kg) 45–54 31.8 (7.4) 44.9 (12.3) 13.2 (1.0–25.4)* 55–65 34.1 (6.1) 43.0 (14.5) 9.0 (3.5–14.4)* All 33.5 (6.3) 44.3 (13.0) 10.9 (7.0–14.8)* Lifting Overhead (kg) 45–54 19.8 (2.9) 20.1 (4.8) 0.4 (−4.4–5.2) 55–65 17.3 (3.9) 18.9 (4.6) 1.6 (−1.4–4.5) All 17.9 (3.7) 19.7 (4.8) 1.8 (−0.7–4.3) Carry 2 hand (kg) 45–54 46.3 (13.4) 46.4 (11.0) 0.1 (−11.0–11.3) 55–65 35.7 (11.5) 43.1 (12.7) 7.4 (−0.9–15.7) All 38.5 (12.5) 45.4 (11.7) 7.0 (0.7–13.1)* Overhead work (s) 45–54 236 (103) 269 (127) 33 (−93–160) 55–65 207 (61) 270 (102) 63 (−0.4–127.1) All 214 (72) 270 (119) 55 (−7–117) Dynamic bend (s) 45–54 51 (7) 47 (6) −4 (–11–3) 55–65 62 (16) 66 (128) 4 (−74–82) All 60 (15) 48 (7) −12 (3–21)* Rep.