An extrarenal pelvis should be in a surgeon’s differential for abdominal masses when imaging is not conclusive in the contrary. “
“Augmentation cystoplasty using an intestinal tract is indicated for patients with a deterioration of bladder storage function resistant to pharmacologic or other conservative interventions. For example, patients with http://www.selleckchem.com/products/Imatinib-Mesylate.html neurogenic

bladder caused by spinal cord injury, contracted bladder caused by urogenital tuberculosis, or interstitial cystitis are candidates for augmentation cystoplasty. Malignant transformation of primary or substitutional bladder epithelium after augmentation cystoplasty is rare and needs a long postoperative period.1 However, these malignant tumors are frequently aggressive Crizotinib cell line and associated with a poor prognosis,2 and the mechanisms of carcinogenesis are unclear. We previously reported a case of a 62-year-old woman with tubulovillous adenoma that developed 44 years after ileocystoplasty.3

Two more years later, she developed bladder adenocarcinoma. The adenoma-carcinoma sequence has been implicated in the multistep processes of intestinal carcinogenesis in colon cancer.4 To the best of our knowledge, this is the first case report to provide histopathologic evidence of the adenoma-carcinoma sequence in the bladder after augmentation cystoplasty. A 16-year-old female patient underwent right nephrectomy for renal tuberculosis. Augmentation ileocystoplasty for tuberculosis contracted bladder was performed at 18 years. Left nephrostomy was required at 38 years because of hydronephrosis and repeated pyelonephritis. In March 2005, 44 years after ileocystoplasty, the patient presented at our hospital with gross hematuria. Cystoscopy revealed the multiple papillary tumors in the region of the ileovesical anastomosis. Transurethral resection of the bladder tumor (TURBT) was performed. Histopathologic examination revealed tubulovillous adenoma (Fig. 1A). The tumor recurred 4 times, necessitating repeated TURBT in April 2005, November 2007, March 2008, and October 2008. Histopathologic diagnosis was tubulovillous adenoma at the

second TURBT in 2005, but the diagnosis of well-differentiated adenocarcinoma, pTa, (Fig. 1B) was made at the third TURBT in 2007, 46 years after ileocystoplasty. The fourth and fifth TURBT also revealed well-differentiated adenocarcinoma. In January 2009, radical cystectomy with ileal conduit diversion was performed because of incomplete resection during the fifth TURBT. Macroscopic findings (Fig. 2A) and histologic examination (Fig. 2B) revealed that the tumor developed around the region of ileovesical anastomosis. Histopathologic diagnosis was well-differentiated adenocarcinoma, pTa, u-rt0, u-lt0, ur0, ew0, ly0, v0, pN0 (Fig. 2B). The postoperative course was uneventful, and the left nephrostomy catheter was removed.