(C) 2011 American Institute of Physics. [doi:10.1063/1.3638694]“
“Purpose: To prospectively compare the effect of intravenous injection of low-osmolar iopamidol with that of intravenous injection of iso-osmolar iodixanol on heart rate (HR) during nongated chest computed tomographic (CT) angiography.
Materials and Methods: This multicenter study was approved by local institutional review boards, and patients provided written informed consent. Patient enrollment and examination at Cilengitide price centers in the United States complied with HIPAA regulations. One hundred and thirty patients (54 male; mean age, 52 years) clinically suspected of having pulmonary embolism were referred for pulmonary CT angiography and
were randomly assigned to receive 80 mL of either iopamidol (370 mg of iodine per milliliter, n = 63) or iodixanol (320 mg of iodine Lonafarnib supplier per milliliter, n = 67) at a rate of 4 mL/sec. HR (measured in beats per minute) was monitored from 5 minutes before the start of injection to the end of imaging, and precontrast HR and maximum postcontrast HR were recorded. Student t and chi(2) tests were used for continuous and categorical variables, respectively.
Results: Precontrast HR in patients who received iopamidol (mean, 81 beats per minute +/- 18 [standard deviation]) was similar to that in patients who received iodixanol (mean, 77 beats per minute +/- 17) (P = .16). Mean postcontrast HR was 87 beats per minute +/- 17 and 82 beats per minute +/- 18 (P = .16) in
the iopamidol and iodixanol groups, respectively. Mean increase from precontrast HR to postcontrast HR was 5 beats per minute +/- 9 and 5 beats per minute +/- 7 (P = .72) in the iopamidol and iodixanol groups, respectively. Thirty-five (56%) of the 63 patients who received iopamidol and 33 (49%) of the 67 patients who received iodixanol had an HR increase of fewer than 5 beats
per minute, 15 (24%) and 18 (27%) patients, respectively, had an increase of 5-9 beats per minute, and four (6%) and three (4%) patients, respectively, had an increase of more than 20 beats per minute. These proportions were not significantly different between the groups (P = .51, chi(2) test).
Conclusion: High-rate intravenous administration of 80 mL of iopamidol and iodixanol during pulmonary CT angiography slightly increased HR; there was no difference in HR between the contrast agent groups.”
“Background
Chronic myelogenous Selleckchem LY3023414 leukemia (CML) presenting as multiple skin chloromas is an extremely lore manifestation. Though often seen in acute myelogenous leukemia, to date there have been no reporter) cases of CML presenting its multiple skin chloromas in the chronic phase. Chloromas in blastic phase of CML at different body sites have been reported previously.
Case
A 53-year-old. African American male presented to his primary case provider with multiple skin nodules. A complete blood found showed a high white cell count, for which he was transferred to a University tertiary care center.