(C) 2011 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 41:445-454″
“One new triterpenoid saponin, named piptadeniaoside (1), along with two known saponins (2-3) have been isolated from the stem bark of Piptadeniastrum africanum. After previous isolation of flavone derivatives from this plant, new phytochemical investigations were

performed for its saponin content. Their structures were established by direct interpretation of their spectral data, mainly HRESIMS, 1D NMR (H-1, C-13 NMR, DEPT) and 2D NMR (COSY, NOESY, HSQC and HMBC), and by comparison with the literature data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.”
“P>The hallmark of Schimmelpenning-Feuerstein-Mims syndrome (SFMS) is a systematized nevus sebaceous that MK-8931 in vitro follows Blaschko lines and usually involves the face. It represents a rare congenital nevus syndrome with alterations of skin, bones, CNS, eyes and heart. Nevi sebacei can proliferate and develop into epithelial tumors like trichoblastoma, syringocystadenoma and basal cell carcinoma. The histological differentiation between basal cell carcinoma and trichoblastoma is difficult. We present an adult woman with SFMS who was followed by multiple specialties since birth buy Natural Product Library without the correct diagnosis being made. She was referred to us with

the diagnosis of multiple basal cell carcinomas of head and face. Our diagnosis of systematized nevus sebaceus was crucial for the correct classification of SFMS. We identified multiple trichoblastomas Saracatinib nmr in the nevi sebacei and could exclude basal cell carcinomas. The essential clue was the detection of multiple Merkel cells within the epidermal layer by cytokeratin 20 staining.”
“Background: Pulmonary manifestations of Wegener’s granulomatosis (WG) are present in 45% of cases at the onset of the disease, and they reach 85% of the patients during its evolution. Pulmonary affection usually starts with unspecific symptoms such as cough, dyspnea, hemoptysis, and pleuritis. Pulmonary nodules are 1 of the most common manifestations. The prevalence of pleural affection is 10 to 20%. However, spontaneous pneumothorax

is extremely rare. Although its real incidence is unknown, according to different classic series, it ranges between 3 and 5% of the cases.

Objective: To present a new case of spontaneous pneumothorax in a patient suffering WG and a brief review on this subject.

Methods: We report our experience in a case of spontaneous pneumothorax due to WG. We also review the literature through a PubMed search between 1960 and 2010, using a broad range of keywords related to WG and spontaneous pneumothorax. Publications were evaluated for the demographic features of patients, manifestations of the disease, and outcome.

Results: Despite the large prevalence of the respiratory involvement, spontaneous pneumothorax is extremely rare, with only 21 cases reported in the literature.