CKD-EPI CysC showed the best performance, detecting 66% of GFRs <60 (concordance 79%, underdiagnosis 21%) and 25% of GFRs <30 (concordance 25%). Severe malnutrition increased with MELD score. By RFH-SGA: 5.7% in MELD <10, 12.9% in MELD 11-14, 24.1% in
MELD >15 were malnourished, and by BIA 26%, 29% and 38% respectively. This could contribute to the overestimation of renal function in this population when sCr is used. Conclusion: Estimated GFR by CysC formulas overestimated GFR by DTPA-Tc99 in a lesser degree than sCr formulas. SCr may not be an adequate measure of renal function in this population. Nutritional status could be used to weigh parameters of renal function in malnourished cirrhotic patients. The most benefited group could be patients with MELD >15, candidates for liver transplantation, since an impaired selleck screening library renal function affects postransplant outcomes, and some of them could require liver-kidney transplant. Disclosures: The following people have nothing to disclose: Jonathan Aguirre-Valadez, Haydee Verduzco-Aguirre, Ariadna K. Flores-Balbuena, Octavio R. García-Flores, Ricardo Macías-Rodríguez, Cristino Cruz-Rivera, Jose A. Niño-Cruz,
Ignacio Garcia, Aldo Torre Background: Cardiac ascites, while frequently diagnosed, has no clear mechanism described in the literature. A portal pressure greater than 10 mmHg is often cited as a requirement for cirrhosis-related ascites. However, there is no minimum right atrial (RA) pressure required for cardiac this website see more ascites formation found in the literature. In a group of heart failure (HF) patients referred for cardiac transplantation (CT), we attempted to identify patient characteristics and predictors associated with the development of cardiac ascites. Methods: All adult patients with HF referred to Mount Sinai Medical Center
for CT from January 2010 to August 2013 were retrospectively assessed. Patients were divided into two groups based on abdominal imaging: those with and without clinically significant ascites, which was defined as having “moderate” to “large” ascites. Demographic information, serum laboratory values, and results of transthoracic echocardiograms (TTE) and right heart catheterizations (RHC) were compared between the groups. Results: Of the 225 patients assessed, 29 patients were excluded due to lack of abdominal imaging. Of the 196 study patients, 29 (14.8%) patients had clinically significant ascites. There were no significant differences in age, gender, ethnicity/race, and etiology of heart disease in the two groups. However, the ascites group had higher creatinine (2.3 vs 1.6 mg/dL, p=0.03), higher BUN (50.1 vs 32.6 mg/dL, p<0.01), higher brain natriuretic peptide (1611 vs 1103 pg/mL, p=0.04), and lower albumin (3.3 vs 3.6 g/dL, p=0.03). On TTE, the ascites group had more severe right ventricular (RV) dilatation (p=0.03) and more tricuspid valve regurgitation (p<0.01).