In whole plant and leaves oils it ranged from (43.49–47.73%), whereas in spikes and husk, the compound constituted 60.06% and 56.80%, respectively. BIBW2992 manufacturer The amount of 1-methyl-2-methylene trans-decalin was also decreased in whole plant (16.69%) and husk (12.20%), while increased in leaves (36.11%) and spikes (9.08%) as compared to D1. In D2 stage, the amount

of trans-caryophyllene was increased which ranged from (2.55–15.85%). D3 stage: In D3 stage of seed sowing the percentage of first major compound (perilla ketone) was found 51.17%, 58.94%, 49.31% and 61.12% in whole plant, leaves, spikes and husk, respectively. The average amount of 1-methyl-2-methylene trans-decalin was also found lesser as compared with D1 and D2. trans-Caryophyllene was detected in appreciable amounts in D3 sowing stage (1.89–16.44%). Earlier studies on the essential oils of P. frutescens and other species 3, 4, 5, 6, 7, 8, 9, 10 and 11

revealed that perilla ketone and perillaldehyde are the two major chemotypes which were reported in different countries, though in some studies egomaketone, limonene, piperitone, β-caryophyllene and rosefuran were also reported as the major components in perilla species. On the basis of comparative composition of the essential oils C59 wnt manufacturer of whole plant, leaves, spikes and husk at three sowing times, it was found that the amounts of first 2 major compounds, especially perilla ketone were higher in D1 as compared with D2 and D3 sowing times. Although all the samples were found qualitatively similar yet quantitative variations were occurred in their compositions. The other components which were present in remarkable amounts were linalool; 1H-indene, 1-ethylidene octa hydro-7a-methyl; imidazole, 4-trifluoroacetyl; trans-α-bergamotene and caryophyllene oxide. Perilla ketone was also found in appreciable amounts in two previous studies on the essential

oils of P. frutescens, which constituted 35.6% 5 and 55.6% 6 of the oil, but in present investigation, the samples from all the stages were found rich in the name of perilla ketone. All authors have none to declare. The else authors are thankful to the research and field staff of Centre for Aromatic Plants (CAP) for their valuable support during course of study. “
“Epilepsy is the second most common chronic neurological condition. The overall incidence of epilepsy in India has been reported to be around 8 million. Hypertension can lead to seizures through vascular brain damage that might or might not involve manifest stroke.1 The striking synergism between hypertension and stroke are more epileptogenic than other. The contribution of noradrenergic neurotransmission to the seizure susceptibility and epilpeptogenesis is gaining more attention recently. Various studies showed that activation of β-adrenoceptor may progress the epileptic phenomena by increasing their rate of spontaneous epileptoform discharge in hippocamal slices.