Mortality and morbidity rates were high in our patients (14.51 % and 35.48 %, respectively). Moreover, the findings may suggest that health care policy makers should design a plan to warn susceptible women of the risk of CVST and educate them the ways to prevent it. Acknowledgment We would like to thank Ms. Hosseini and Ms. Gholami from Shiraz Neurosciences Research Center for their kind assistance. Conflict of Interest: None declared
A study, performed by the National Heart Association of Malaysia, has reported

that the majority of coronary heart disease (CHD) patients are in their forties and fifties.1 It has also been reported that CHD is a major cause of premature deaths in Malaysia, and has significant psychosocial and Inhibitors,research,lifescience,medical economic implications for the country.2 The anxiety and depression of CHD patients have significant impact on their compliance with treatment, and prognosis. The preconceived ideas and past Caspase inhibitor problems experienced by the patients may exacerbate their physical symptoms, and may subsequently affect their quality of life.3 Studies have reported Inhibitors,research,lifescience,medical that CHD

individuals are prone to suffer from mood labile, and end up with overt depression.4 A previous study has revealed that 33-64% of CHD patients Inhibitors,research,lifescience,medical experienced severe emotional reactions in the first four months after a heart attack.5 In addition, there was an increased cardiac mortality in patients who developed post-myocardial infarction depression, while pre-myocardial infarction depression did not carry any additional risk of mortality.5 Inhibitors,research,lifescience,medical Moreover, in post-acute myocardial infarction (AMI) patients assessed using hospital anxiety and depression score (HADS), 13.6% showed moderate and severe anxiety, and 7.3% showed moderate or severe depression at the end of three months.5 Anxiety and depression were frequent Inhibitors,research,lifescience,medical problems encountered

by the CHD patients.6 It has been shown that anxiety and depression strongly affect overall well-being, cardiac and non-specific symptom reporting, and overall quality of life.6 This has been reported as a convergent evidence supporting the role of emotional stimuli in triggering off acute coronary syndrome (ACS), unstable angina and myocardial infarction.6 next Emotion acts as a trigger for individuals belonging to lower socio-economic status. Emotional upsets often trigger off the pathophysiological changes underlying plaque rupture, formation of a prothrombotic vascular environment, thrombus formation, and other neuroendocrine and autonomic processes, which results in cardiac rhythm disturbances.6,7 Confounding psychosocial factors have a directrelationship with the development of atherosclerosis and heart diseases. Significant confounding factors include depressive and anxiety disorders, anger, hostility and chronic life stressor.8 Other confounding factors include low socio-economic status, poor social support, work stress, and marital problems.