The Korean version of the SRS-22 questionnaire and the previously validated Short
Form-36 (SF-36) outcome instruments were mailed to 102 patients who had been treated surgically for idiopathic scoliosis. Eighty-two patients selleck compound responded to the first mailing of questionnaires and 64 of the first-time responders returned their second survey. The average age of the 64 patients (56 females and 8 males) was 18.3 years. Reliability assessment was determined by estimating Cronbach’s alpha and intraclass correlation coefficient (ICC), respectively. Concurrent validity was evaluated by comparing SRS-22 domains with relevant domains in the SF-36 questionnaire using Pearson’s correlation coefficient.
The study demonstrated satisfactory internal consistency (Cronbach’s alpha = 0.80-0.89) for function/activity, pain and mental
health, and good consistency (Cronbach’s alpha = 0.50-0.79) for the remaining domains. The ICC of all domains demonstrated excellent test/retest reproducibility. Considering concurrent validity, 3 domains showed excellent correlation, 9 domains good, 25 domains moderate, and 3 domains poor.
The adapted Korean BIIB057 version of the SRS-22 questionnaire was successfully translated and showed acceptable measurement properties, and as such, is considered suitable for treatment outcome assessments in the Korean-speaking patients with idiopathic scoliosis.”
“The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire (R) 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (499%).
High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D-90) to 62.8 +/- 4.1 mu m and 64.9 +/- 3.3 mu m, respectively, while magnetic stirring produced microparticles with a size of 84.1 +/- 1.4 mu m. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. AG-881 research buy In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation.”
“A 63-year-old woman was admitted because of sudden ischemic hemyplegia promptly cleared up by intravenous (IV) recombinant tissue plasminogen activator. On subsequent 2-dimensional echocardiogram, we observed an extremely mobile homogeneous mass attached by a short stalk to ventricular insertion of anterolateral papillary muscle chordae tendineae. The mass was surgically removed.