The main advantages of incorporate insulin into SLN would be the enhancement of transmucosal transport and protection from the degradation in the GIT. 7. Conclusions Lipids and lipid nanoparticles are promising for oral and peroral administration route for drugs, proteins, and peptides. Theses matrices are able to promoting controlled release of drugs in GIT and reducing absorption variability. In addition, these matrices can be absorption as food lipids together with drugs improving the bioavailability. These systems present several advantages, including drug protection and excipients of GRAS status, which decreases the Inhibitors,research,lifescience,medical danger of acute and chronic

toxicity. In addition, the oral administration of lipids nanoparticles is possible as aqueous dispersion

or alternatively transformed Inhibitors,research,lifescience,medical into a traditional dosage forms such as tablets, pellets, capsules, or powders in sachets. Acknowledgments The authors wish to acknowledge Fundação para a Ciência e Tecnologia do Ministério da Ciência e Tecnologia, under reference no. ERA-Eula/0002/2009. Sponsorship of P. Severino was received from CAPES (Coordenação Inhibitors,research,lifescience,medical Aperfeiçoamento de Pessoal de Nivel Superior) and FAPESP (Fundação de Amparo a Pesquisa). Sponsorship of T. Andreani was received from Fundação para Ciência e Tecnologia (SFRH/BD/60640/2009).
Lipid nanocapsules (LNCs) Inhibitors,research,lifescience,medical are a new generation of biomimetic nanovectors composed of an oily core of medium-chain triglycerides of capric and caprylic acids known under the commercial name of Labrafac that is surrounded by a shell composed of lecithin and a pegylated surfactant called Solutol HS 15. Solutol is a mixture of free PEG 660 and PEG 660 hydroxystearate and oriented towards the water phase. Lecithin is composed of 69% phosphatidylcholine soya bean

and is generally Inhibitors,research,lifescience,medical used in small proportions to significantly increase LNC stability [1, 2]. Their structure mimics lipoproteins [3, 4] while have a hybrid structure between polymer nanocapsules and liposomes. LNCs present a great physical stability up to 18 months with size ranges from 20 to 100nm. They are prepared by a phase inversion of an oil/water emulsion due to Brefeldin_A thermal manipulation and in the absence of organic solvents with good monodispersion [5]. The aqueous phase consists of MilliQ water plus sodium chloride salt, which helps to decrease the phase-inversion temperature (PIT) [5, 6]. Preparation of LNCs involves two steps. In the first step all mixed components are heated from room temperature up to T2 temperature, above the PIT, to obtain a W/O emulsion. Then the temperature is dropped to T1 below the PIT, by a cooling process that leads to the formation of an O/W emulsion.