The SNPs were tightly linked (r^2 > 0.94) but not in absolute linkage disequilibrium between each other. We could not find any difference in the predictive impact of any of these 3 SNPs with regard to susceptibility to HCV, treatment outcome, and early viral response. However, in subgroup analysis consisting of patients with/without minor haplotypes, patients with favorable rs8099917 TT, linked to unfavorable genotype of rs368234815 and rs12979860, showed poor initial viral response compared to those with PI3K Inhibitor Library price all favorable genotypes with respect to these SNPs (p = 0.0022). Conclusions: As a whole, none of the IFNL4/IL-28B SNPs showed

superior predictability compared to the others with regard to both, susceptibility to and treatment-induced resolution of HCV infection in Japanese population. However, findings in early viral response in patients with minor haplotypes Cobimetinib ic50 suggest that rs368234815 and rs12979860 may have better predictive impact on response to PEG-IFN plus RBV therapy in patients with minor haplotypes consisting of these SNPs. Disclosures: Kazuaki Chayama – Consulting: Abbvie; Grant/Research

Support: Dainippon Sumitomo, Chugai, Mitsubishi Tanabe, DAIICHI SANKYO, Toray, BMS, MSD; Speaking and Teaching: Chugai, Mitsubishi Tanabe, DAIICHI SANKYO, KYO-RIN, Nihon Medi-Physics, BMS, Dainippon Sumitomo, MSD, ASKA, Astellas, AstraZeneca, Eisai, Olympus, GlaxoSmithKline, ZERIA, Bayer, Minophagen, JANSSEN, JIMRO, TSUMURA, Otsuka, Taiho, Nippon Kayaku, Nippon Shin- yaku, Takeda, AJINOMOTO, Meiji Seika, Toray The following people have nothing to disclose: Hidenori Ochi, Daiki Miki, C. Nelson Hayes, Hiromi Abe, Michiaki Kubo Background: Renal impairment together with a more pronounced anemia has recently been reported in about 5% of patients under triple therapy with boceprevir (BOC) or tela-previr (S Mauss et al., Hepatology 2014; 59:46-48). check details In the present interim analysis of the NOVUS observational study we investigated whether renal

impairment at baseline or during treatment determines the frequency of anemia in patients (pts) undergoing BOC triple therapy. Methods: From April 2012 until January 2014, 536 pts with HCV G1 infection were recruited in the ongoing NOVUS study by 97 practices and hospitals in Germany. Pts were treated with pegylated inter- ferons (PegIFN) and ribavirin (RBV) together with BOC for 24 to 44 weeks after a 4 weeks lead-in period with PegIFN/RBV. The present interim analysis was restricted to 292 pts with documented hemoglobin (Hb) and eGFR data from baseline until treatment week (TW) 12. eGFR (mL/min per 1.73 m2) was calculated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Anemia was defined as Hb <10 g/dL.