Therefore, post-operative nausea and vomiting are more common and these patients in these patients.10 In the present study, the incidence rates

of PONV in the placebo, dexamethasone and ondansetron groups were 100%, 54.8% and 49.3%, respectively. The incidence rate and intensity of PONV in the dexamethasone and ondansetron groups were significantly lower than that in the control group. Inhibitors,research,lifescience,medical In the final stages of the study, incidence rate and intensity of PONV in the dexamethasone group was less than that in the ondansetron group. Previous kinase inhibitor Ruxolitinib studies have shown that compared to distilled water, intravenous dexamethasone significantly reduced the rate and intensity of the PONV.11-13 Limited studies have compared the effects of dexamethasone and ondansetron on PONV, Inhibitors,research,lifescience,medical and their findings are contradictory. Erhan et al. conducted a comparative study on ondansetron (4 mg IV), granisteron (3 mg IV) and dexamethasone (8 mg IV) effects given before induction of anesthesia to prevent postoperative PONV in laparoscopic cholecystectomy. They showed that compared to placebo all the three drugs in similar manner significantly reduced the incidence rate of PONV.14 Lopez-Olaondo et al. reported Inhibitors,research,lifescience,medical that dexamethasone was as effective as ondansetron in reducing nausea and vomiting induced by chemotherapy.15 Gupta also concluded that intravenous dexamethasone and ondansetron had a similar effect on PONV prevention.16

Moreover, Munoz et al. showed that the effects Inhibitors,research,lifescience,medical of dexamethasone and ondansetron in preventing PONV were similar.17 However, in another study,18 it was shown that ondansetron was better than dexamethasone. Another study showed that dexamethasone was a little

more effective than ondansetron in preventing post-tonsillectomy PONV.19 Also, a study of 60 patients undergoing laparoscopic cholecystectomy showed that the incidence rate of Inhibitors,research,lifescience,medical PONV in the dexamethasone group was significantly lower (20% versus 43.3%).20 The difference in the findings of the above studies might be related to wide range of differences in sample sizes, patients qualities, type of surgical operations and anesthetic techniques, the way that PONV was defined and studied, and most important of all the dosage Carfilzomib of the antiemetic drugs and the timing of their administration.17,21 The present study showed that dexamethasone was more effective than ondansetron in preventing PONV; therefore, it may be more suitable to be administered in such a situation. In the studies in which no difference was reported between dexamethasone and ondansetron, the use of dexamethasone was preferred. This might be attributed to the lower cost of dexamethasone than that of ondansetron.14 The present study showed that neither dexamethasone nor ondansetron was associated with no significant side effects. The safety of these drugs has already been confirmed.