While there were no instances in this small series of abnormally low StO2 before clinical symptoms of

shock were present, there is also the E7080 in vivo potential for such a device to be useful in early identification of “”sub-clinical”" shock. Equally appealing is the possible use of StO2 in a triage setting in either civilian or military trauma. Such a use has the added CP673451 clinical trial benefit of giving a number to confirm the presence of tissue hypoperfusion for less experienced care providers. These potential benefits have led to the incorporation of StO2 as another tool for early evaluation of trauma patients at several civilian trauma centers. Previous work from our lab in a porcine model of severe hemorrhagic shock identified StO2 as a significant predictor of eventual mortality in this setting [8], with StO2 significantly lower in the cohort of animals that were unsuccessfully resuscitated. Conclusion Near-infrared spectroscopy-derived StO2 reflected and tracked the resuscitation status in the observed severely injured patients suffering battlefield injuries. StO2 has significant potential for use in resuscitation and care of patients with battlefield injuries. About the authors GJB serves as a Colonel in the United States Army Reserve. He’s also Professor of Surgery and Anesthesia, Chief of the Division of Surgical Critical Care/Trauma, Vice Chair of Perioperative Services and Quality Improvement

in the Department of Surgery AZD5582 ic50 at the University of Minnesota, and a Fellow of the American College of Surgeons. JJB served as a postdoctoral research associate at the Division of Surgical Critical Care/Trauma and currently is a general surgery resident in the Department of Surgery at the University of Minnesota. Acknowledgements The authors would like to acknowledge the contributions of the staff of the 228th Combat Support Hospital, Company B. References

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