2010; Paton et al. 2008], despite guidelines to the contrary [Langan and Shajahan, 2010; Taylor, 2010a; National

Institute for Clinical Excellence, 2009]. Compelling any patient to have potentially dangerous or even fatal high doses of medication is extremely problematic. Indeed, a study of 93,300 patients treated with antipsychotics and 186,600 matched controls found that high doses (>300mg chlorpromazine equivalent) of first- and second-generation antipsychotics were associated with increased rates of sudden Inhibitors,research,lifescience,medical cardiac death [Ray et al. 2009]. Thus, whilst it is probable that the requirement for a SOAD to sanction treatment plans has already reduced the potential number on a CTO who would otherwise have been prescribed high doses, more needs to be done regarding prescribing monitoring for this patient group. SOAD certification Inhibitors,research,lifescience,medical SOAD certification involves an important safeguard for CTOs but this is subject to delay in our sample as LY2157299 chemical structure highlighted by the low rate of SOAD certification within the specified time-frame Inhibitors,research,lifescience,medical (14.9%). This is probably in keeping

with national trends and is undoubtedly due to higher than anticipated rates of CTO use across England and Wales. This may be further compounded by some patients failing to attend at the scheduled time but as this was not consistently documented, we were unable to accurately take this Inhibitors,research,lifescience,medical into account for this study. Owing to the debated legality of community treatment orders without completed SOAD certification, a temporary measure of using emergency treatment orders (section 64) was instigated but this has proved unpopular and is arguably also unlawful in this specific context. Until

the shortage of SOADs is resolved, we are likely to Inhibitors,research,lifescience,medical continue facing the problem that many patients are being required to take medication that has not been approved nor had full legal process. As the system further adjusts to cope with the new Mental Health Act, it is hoped that several of these early problems for CTOs can be resolved. Contributions MXP designed the study, conducted the analyses, drafted the article and takes responsibility for the integrity of the data and the accuracy of the data analysis. JM, MKB, JG and KB contributed to the data collection, analyses, and CYTH4 interpretation. JB, FH, DT, GS, TL and ASD contributed to the data analysis and interpretation. All authors were involved in the drafting of this article and approved the final published version. Footnotes The authors acknowledge support from the Department of Health via the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to South London and Maudsley NHS Foundation Trust (SLAM) and the Institute of Psychiatry at King’s College London.