4 In chronic cases in

4 In chronic cases in selleck chem EPZ-5676 which the distal stump of the biceps tendon cannot be mobilized up to the radial tuberosity, various reconstruction methods were described including the use of fascia lata, semitendinosus tendon, palmaris longus tendon, calcaneal tendon and tendons of the flexor carpi radialis. CONCLUSION The method presents good results as do the other techniques, yet it reduces the risk of adhesion on the flexor fold of the elbow. Footnotes Study conducted at Hospital IFOR, S?o Bernardo do Campo, SP, Brazil. Citation: Pascarelli L, Righi LCS, Bongiovanni RR, Imoto RS, Teodoro RL, Ferro HFA. Technique and results after distal braquial biceps tendon reparation, through two anterior mini-incisions. Acta Ortop Bras. [online]. 2013;21(2):76-9. Available from URL: http://www.scielo.br/aob.

There are few methods for the treatment of spinal cord lesions, and no really effective treatment is available. 1 Surgical treatment for mechanical stabilization and decompression may be performed in cases of unstable fractures with spinal cord lesion, and the use of drugs for the treatment of spinal injuries has been extensively studied. Experiments with the use of chemicals are conducted mostly with the aim of promoting nerve regeneration, and in an attempt to inactivate or reduce the secondary cascade of events that follows spinal injuries. However, only two of these drugs are already used clinically: monosialoganglioside (GM1) and methylprednisolone, 2 although there is no consensus as to the benefits of their indication.

3 GM1 is an antineurotoxic, anti-inflammatory, neuroprotector agent, essential in neuronal excitability of myelinated and unmyelinated fibers. It also promotes neuronal development, growth, differentiation and maturation, and reduces the intensity of Walerian degeneration. 4 Many researchers also advocate the use of physical means in the treatment of spinal injuries in an attempt to obtain better results. Hypothermia is one such alternative; it reduces post-traumatic metabolism and energy consumption, decreasing the intensity of secondary lesions, hypoxia and ischemia, as well as apoptosis of neurons and glial cells. 5 – 7 A new type of laser used for drug administration was recently developed in Italy (Laser Ice Med). It allows transcutaneous penetration of particles mixed in a gel at low temperature, by means of 635nm, 50mW parallel beams.

Santos et al. presented, at the European Congress of Neuroscience, their research on the effects of laser with GM1 in trauma associated with cord and peripheral nerve injury in Wistar rats. GM1, administered daily by the transdermal route for 60 days, resulted in regeneration superior to that of the control group, in the Dacomitinib histological and functional evaluations of the sciatic nerves and spinal cords. 8 The results of each GM1 and “laser ice” therapies are, however, still not satisfactory, which prompted us to study a possible synergy between them.

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