As a consequence, the qualitative environmental target “seas without significant impacts by anthropogenic eutrophication” was set and it was acknowledged that further reductions in nutrient inputs are necessary to achieve GES. The EU Water Framework Directive׳s (WFD, 2000/60/EC) objectives are similar to the MSFD. The WFD aims to establish and/or maintain “good ecological status” and “good chemical status” for all surface waters by 2015 and spatially isocitrate dehydrogenase inhibitor overlaps with the MSFD

in coastal waters up to the baseline plus 1 nautical mile (12 nautical miles for the chemical status). The adoption of the WFD in 2000 can be regarded as a major landmark since the management of rivers, lakes, coastal waters, and ground waters was no longer based on national or political boundaries but on river basins. For all WFD river

basins comprehensive River Basin Management Plans linking coastal water objectives to measures in respective catchments had to be established by 2009 and need to be reviewed by 2015. “Good ecological status” according to the WFD is defined based on reference conditions that describe a “high status with no, or very minor disturbance from human activities” [18]. Subsequently reference conditions have been developed for different biological elements Small molecule library ic50 [2], [9] and [33] and hydro-chemical parameter [11] as well as different surface waters [5], [38], [39] and [58] all over Europe. Similar activities took place in the Baltic [12], [13], [26] and [41] and in German waters [4], [7], [8], [10] and [42]. Of the 44 German Baltic coastal water bodies assessed under the WFD in 2009 all but one failed to achieve “good ecological status” mainly due to eutrophication effects. Recognizing that most problems in the marine environment are transboundary in nature the MSFD establishes European marine Amoxicillin regions and sub-regions on the basis of geographical

and environmental criteria and demands that GES is achieved at this spatial scale. The Baltic Sea is one out of four European marine regions and subject to an existing Regional Sea Convention, the Helsinki Convention, signed in 1974. In 1992 coastal waters became part of the convention area. The governing body is the Helsinki Commission (HELCOM). In 2007, the HELCOM Baltic Sea Action Plan (BSAP), a comprehensive program to restore good ecological status of the Baltic marine environment by 2021, was adopted. The BSAP can be regarded as a regional contribution to achieving GES according to the MSFD for those HELCOM Contracting Parties being also EU Member States. In the BSAP 2007 HELCOM Contracting Parties agreed on maximum allowable inputs of nutrients (MAI) in order to reach GES of the Baltic Sea and committed to country-wise provisional nutrient reduction requirements (CART) [14].