Invest Radiol 2011, 46:441–449. doi:10.1097/RLI.0b013e3182174fadCrossRef 12. Klement G, Huang P, Mayer B, Green SK, this website Man S, Bohlen P, Hicklin D, Kerbel RS: Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res 2002, 8:221–232. 13. Ellington AD, Szostak JW: In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346:818–822.CrossRef 14. Yigit MV, Mazumdar D, Kim HK, Lee JH, Odintsov B,

Lu Y: Smart “Turn-on” magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles. ChemBioChem 2007, 8:1675–1678.CrossRef RO4929097 15. Sun S, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li G: Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc 2003, 126:273–279.CrossRef 16. Lim EK, Yang J, Suh JS,

Huh YM, Haam S: Self-labeled magneto nanoprobes using tri-aminated polysorbate 80 for detection of human mesenchymal stem cells. J Mater Chem 2009, 19:8958–8963.CrossRef 17. Anton N, Benoit JP, Saulnier P: Design and production of nanoparticles formulated from nano-emulsion templates – a review. J Control Release 2008, 128:185–199.CrossRef 18. McCarthy JR, Weissleder R: Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv Drug Deliv Rev 2008, 60:1241–1251.CrossRef 19. Yang J, Eom K, Lim EK, Park J, Kang Y, Yoon DS, Na S, Koh EK, Suh JS, Huh YM, Kwon TY, Haam S: In situ detection of live cancer cells by using bioprobes based on Au nanoparticles. Langmuir 2008, 24:12112–12115.CrossRef 20. Choi J, Yang J, Park J, Kim E, Suh JS, Huh YM, Haam S: Specific near-IR absorption imaging of glioblastomas using integrin-targeting gold nanorods. Adv Funct Mater 2011, 21:1082–1088.CrossRef 21. Zhang Y, Yang M, Portney N, Cui D, Budak G, Ozbay E, Ozkan M, Ozkan C: Zeta potential: a surface electrical characteristic to probe the interaction of nanoparticles with normal

and cancer human breast epithelial cells. Biomed Microdevices 2008, 10:321–328.CrossRef 22. Aldol condensation Jung CW, Jacobs P: Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. Magn Reson Imaging 1995, 13:661–674.CrossRef 23. Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC: MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials. Neoplasia 2002, 4:480–485.CrossRef 24. McConville P, Hambardzumyan D, Moody JB, Leopold WR, Kreger AR, Woolliscroft MJ, Rehemtulla A, Ross BD, Holland EC: Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma. Clin Cancer Res 2007, 13:2897–2904.CrossRef 25.