Nucleic Acids Res 2002,30(5):1091–1102 PubMedCentralPubMedCrossRe

Nucleic Acids Res 2002,30(5):1091–1102.PubMedCentralPubMedCrossRef 46. Klein JR, Dunny GM: Bacterial group II introns and their association with mobile genetic elements. Front Biosci 2002, 7:D1843-D1856.PubMedCrossRef 47. Brakhage AA, Al-Abdallah Q, Tüncher A, Spröte P: Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors. Phytochemistry 2005,66(11):1200–1210.PubMedCrossRef 48. Liras P, Rodríguez-García

A, Martín J: Evolution of the clusters of genes for beta-lactam antibiotics: a model for evolutive combinatorial assembly of new beta-lactams. Int Microbiol 1998,1(4):271–278.PubMed 49. Hacker J, Hochhut B, Middendorf B, Schneider G, Buchrieser C, Gottschalk G, Dobrindt U: Pathogenomics of mobile genetic elements of toxigenic bacteria. Int J Med Microbiol 2004,293(7–8):453–461.PubMedCrossRef SBE-��-CD mouse 50. Martínez JL: Bacterial pathogens: from natural ecosystems to human hosts. Environ Microbiol 2013,15(2):325–333.PubMedCrossRef 51. Matter AM, Hoot SB, Anderson PD, Neves SS, Cheng YQ: Valinomycin biosynthetic gene cluster in Streptomyces : conservation, ecology and evolution. Plos

One 2009.,4(9): 52. Van der Auwera GA, Timmery S, Hoton F, Mahillon J: Plasmid exchanges among members of the Bacillus cereus group in foodstuffs. Int J Food Microbiol 2007,113(2):164–172.PubMedCrossRef 53. Ward JM, Grinsted J: Physical and genetic analysis of the Inc-W group plasmids R388, Sa, and R7K. Plasmid 1982,7(3):239–250.PubMedCrossRef 54. Sambrook J, Fritsch E, Maniatis T: Molecular cloning: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989. 55. Andrup L, Barfod KK, Jensen GB, Smidt L: Detection of large plasmids from the Bacillus cereus group. Plasmid 2008,59(2):139–143.PubMedCrossRef 56. Kurtz S, Phillippy A, Delcher AL, Smoot M, Shumway M, Antonescu C, Salzberg

SL: Versatile and open software for comparing large genomes. Genome Biol 2004.,5(2): Competing interests The authors declare that they have no competing interests. Authors’ contributions XM carried out the mating-out and transposition experiments, and wrote the paper; KX performed the bioinformatics analysis; LY carried out primer walking and partial sequencing; ZY revised the paper; Oxalosuccinic acid XH designed the study, constructed the recombinant plasmid, analyzed the data and wrote the paper; JM designed the study, analyzed data and revised the paper. All authors read and approved the final manuscript.”
“Background The emerging New Delhi metallo-β-lactamase (NDM), an acquired class B carbapenemase that was first detected in Klebsiella pneumoniae isolate from a Swedish patient of Indian origin has become a major public health concern worldwide [1]. Two cases of the new variant, NDM-4, have been recently described in isolated find more recovered from patients previously hospitalized in India and Cameroon [2, 3]. In Italy, a few cases of NDM-1 producing E.coli and K.

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