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K, Yoshie M, Kutsukake M, Sakurai T: Insulin-like growth factor binding protein-7 (IGFBP7) blocks vascular endothelial cell growth factor (VEGF)-induced angiogenesis in human vascular endothelial cells. Eur J Pharmacol 2009, 610:61–67.PubMedCrossRef 32. Usui T, Murai T, Tanaka T, Yamaguchi K, Nagakubo D, Lee CM, Kiyomi M, Tamura S, Matsuzawa Y, Miyasaka M: Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as AZD3965 clinical trial an inducible marker for activated endothelial cells. Int Immunol 2002, 14:1273–1282.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions RC carried out the design of the study and molecular biological experiments; HC drafted the manuscript; JL performed the statistical analysis; PJ carried out the pathologic examination studies and western blot analysis; WS carried out the animal experiments; BVD-523 ic50 LX carried out the RT-PCR
and immunohistochemistry; YT carried out the design Phosphoprotein phosphatase of the study. All authors read and approved the final manuscript.”
“Introduction Breast cancer is the most common cancer in women worldwide. Around 1.15 million cases were recorded in 2002, representing 23% of all female and 11% overall cancers . Breast cancer incidence rates for 2002 vary internationally by more than 25-fold, ranging from 3.9 cases per 100 000 in Mozambique to 101.1 in the US, in part reflecting low screening rates and incomplete reporting in developing countries
. Breast cancer is fatal in almost half of all cases. It is the leading cause of cancer death from cancer among woman worldwide, accounting for 16% of cancer deaths in adult women [1, 2]. Depending on the stage of breast cancer, the treatment is carried out by surgery, chemotherapy, ionizing radiation, hormone therapy and supportive measures that aim to reduce the side effects of treatment. Most patients are treated with chemotherapy in order to prevent the systemic dissemination of basic diseases. Patients are subjected to polychemotherapy – combination of three different drugs which are extremely aggressive and hard to bear. There are several protocols used in the treatment of breast cancer – FEC, FAC and CMF; FEC is the most frequently used protocol. Side effects of polychemotherapy (nausea, vomiting, loss of body weight, hair fall out, insomnia, depression, disorders in blood counts) appear in majority of patients and are the most common reasons for stopping the treatment.