Table 1Stability of clinical diagnosis from 2002 to 2009 (n = 30). An agreement between clinical diagnoses in 2002 and 2009 was quantified by using Kappa statistics. product information Kappa score was 0.747 (95% confidence interval: from 0.548 to 0.945). The strength of agreement is considered to be ��good�� (substantial).3.2. Clinical Subgroup Characteristics according to Change/No Change of Diagnostic CategoryThe 6 individuals (5 males) whose original clinical diagnosis of AS or atypical autism/PDDNOS had changed at Time 2 had a mean age at followup of 21.0 (SD 3.6) years; their IQ ranged from 50 to 102; 5 individuals had low scores (0-1) on the ADOS ��Stereotypical/Repetitive Behaviour�� scale. This was markedly different from the group of 10 (8 males) individuals with an original clinical diagnosis of AD (all of whom were again diagnosed clinically as AD at Time 2).

Their mean age was 19.3 (SD 3.6) years (n.s.), all but 1 had IQ < 50 (P < .001), and all had ADOS Stereotypical/Repetitive Behaviour scores of 2 or more (P < .01). However, the AS/atypical autism/PDDNOS group that remained stable (n = 15, 12 males) did not differ from those that changed, in terms of ADOS Stereotypical/Repetitive Behaviour scores, but they were younger at followup (18.7, SD 2.8 years, P < .05) and IQ tended to be a bit higher (range 73�C114).3.3. Stability of DISCO Algorithm DiagnosisOf all five DISCO algorithm diagnoses, the category of AD was the most stable between 2002 and 2009 (8 of the 10 individuals remained in the same category) (Table 2).

The DISCO algorithm diagnoses of AS and atypical autism showed considerable variability; however, no individual moved out of the overarching ASD category altogether.Table 2Stability of DISCO algorithm diagnosis from 2002 to 2009 (n = 30).An agreement between DISCO algorithm diagnoses in 2002 and 2009 was quantified by using Kappa statistics. Kappa score was 0.299 (95% confidence interval: from 0.099 to 0.500). The strength Entinostat of agreement is considered to be ��fair.��3.4. Correspondence between Clinical Diagnosis and DISCO Diagnosis at Followup (n = 50)The highest agreement/stability between the Clinical ICD-10/DSM-IV diagnosis and DISCO algorithm diagnosis in 2009 was noted for AD (67% complete agreement) and AS (52% complete agreement) (Table 3).Table 3Correspondence between clinical diagnosis and DISCO diagnosis at followup (n = 50).An agreement between clinical ICD-10 diagnosis and DISCO diagnosis in 2009 was quantified by using Kappa statistics.